Comment on "Preserved Feedforward But Impaired Top-Down Processes in the Vegetative State"

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Response to Comment on “Preserved Feedforward But Impaired Top-Down Processes in the Vegetative State”

Wethank King et al. (1) for deconstructing our paper (2) showing impaired top-down processes in the vegetative state (VS). We hope our responses provide some useful clarifications. (i) Regarding the number of patients, it would have been disappointing not to have found a common abnormality in eight well-defined VS patients. If we had needed 50 patients to obtain significant differences, we woul...

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Preserved feedforward but impaired top-down processes in the vegetative state.

Frontoparietal cortex is involved in the explicit processing (awareness) of stimuli. Frontoparietal activation has also been found in studies of subliminal stimulus processing. We hypothesized that an impairment of top-down processes, involved in recurrent neuronal message-passing and the generation of long-latency electrophysiological responses, might provide a more reliable correlate of consc...

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ژورنال

عنوان ژورنال: Science

سال: 2011

ISSN: 0036-8075,1095-9203

DOI: 10.1126/science.1210012